Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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A convenient & general procedure for the preparation of Methyl-4-phenyl-3-oxo butyrate derivatives

Author(s): Veera Reddy. Arava, Laxminarasimhulu. Gorentla, Promod Kumar Dubey

A convenient and general procedure for the preparation of methyl-4-phenyl-3-oxo butyrate derivatives is accomplished by the treatment of benzyl cyanides with potassium methyl malonate & anhydrous ZnCl2 in EDC. The protocol is applied successfully to various phenylacetonitriles by decarboxylative Blaise reaction [1].


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