Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


A convenient synthesis and characterization of 1,2-dihydrpyridine-2-one, pyrido[2,3-d]pyrimidine and thieno [3,4-c]pyridine derivatives

Author(s): Abdalla. G. Al-Sehemi

Cyanoacetanilide (1) was reacted with aminocrotonitrile to give the corresponding 1,2- dihydropyridine (3). Also, 4,6-dimethyl-2-oxo-6-1,2-dihydro-pyridine-3-carbonitriles (7) was synthesized and subjected to some electrophilic reagents to produce compounds 8, 9 and 11. Ternary condensation of (1), aldehyde, and malononitrile (1:1:1 molar ratio) produced aminopyridines (14a-c). Compound (14b) was used in the synthesis of pyrido[2,3-d]pyrimidines 20 and 23 upon treatment with formamide and acetic anhydride respectively. Structures of the titled compounds cited in this article were elucidated by spectrometric data (IR, 1H NMR, and EMS).


SCImago Journal & Country Rank
Recommended Conferences
bornova escort karşıyaka escort osmangazi escort buca escort anne porno fetiş porno anal porno bartın escort burdur escort eskişehir escort escort izmir bursa escort porno escort bayan