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A Facile and Efficient Protocol for the Construction of Oxime Esters from Carboxylic Acids and Evaluation of Their Antimicrobial Activities. | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

A Facile and Efficient Protocol for the Construction of Oxime Esters from Carboxylic Acids and Evaluation of Their Antimicrobial Activities.

Author(s): Berihu Tekluu* and Siddaiah Vidavalur

A facile and efficient protocol for the synthesis of various structurally and electronically divergent oxime esters from carboxylic acids and oximes in the presence of 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) and N-methylmorpholine (NMM) in 1,4-dioxane in high yields (90-97%). The synthesized compounds were assessed for their antimicrobial activities. Among the tested compounds 3d, 3j and 3p showed good antimicrobial activity.


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