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A facile and green synthesis of N-substituted-2-chlorobenzimidazoles | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

A facile and green synthesis of N-substituted-2-chlorobenzimidazoles

Author(s): S. Srinivas Rao*, Ch. Venkata Ramana Reddy and P. K. Dubey

A facile and green synthesis of N-substituted-2-chlorobenzimidazoles (4) under different conditions has been developed. In this method, 2-chlorobenzimidazole (3) was treated with an alkylating agent such as DMS/DES/PhCH2Cl under green conditions i.e., by physical grinding in the presence of K2CO3 at RT or by heating in PEG-600 as green solvent at 1000C or by irradiation with micro-wave at RT to obtain N-alkyl-2- chlorobenzimidazoles (4).


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