GET THE APP

A facile synthesis and pharmacological evaluation of 8,8-dimethyl-5- (aryl/heteroaryl)-7,8,9,10-tetrahydro[b][1,8]naphthyridine-6(5H)- ones as anti-inflammatory and antimicrobial agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

ilbet

süperbetin giriş

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

agariookey oyna istanbul okey

Abstract

A facile synthesis and pharmacological evaluation of 8,8-dimethyl-5- (aryl/heteroaryl)-7,8,9,10-tetrahydro[b][1,8]naphthyridine-6(5H)- ones as anti-inflammatory and antimicrobial agents

Author(s): Srinivasa Rao Jetti, Anjna Bhatewara, Tanuja Kadre and Shubha Jain

8,8-dimethyl-5-(aryl/heteroaryl)-7,8,9,10-tetrahydro[b][1,8]naphthyridine-6(5H)-ones 5(a-f) were synthesized from 5,5-dimethyl-2-arylidinecyclohexane-1,3-diones 3(a-f) on reaction with 2-amino pyrimidine 4 using Amberlyst 15 DRY as a catalyst in anhydrous ethanol. 5,5-dimethyl-2-arylidinecyclohexane-1,3-diones 3(a-f) were synthesized by the reaction of aromatic aldehyde 1 and dimedone 2, using L- proline as a catalyst in aqueous media. The reactions have the advantages of good yield, easy separation and of being environment friendly. The structures of newly synthesized compounds have been established by spectral, elemental analysis and evaluated for their antiinflammatory, antibacterial, and antifungal activity


PDF

rokettube brazzers

Turkish dental care is known to be affordable compared to other countries. If you want an affordible dentist Turkey, check out periodonta. It is heavily recommended for dental patients visiting Turkey