Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

A facile synthesis of 1-(4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl)-5-methyl-3-aryl-1,3,5-triazinane-2-thiones and 3-(4-(1H-imidazo[4,5-b]pyridine-2-yl)phenyl)-5-aryl-1,3,5-oxadiazinane-4-thiones

Author(s): Ajay Kumar R, Dayakar G, I. Sujatha, Kusuma B.

4-(1H-imidazo[4,5-b]pyridin-2-yl)benzenamine (1) reacts with aromatic isothiocyanates to form compound 2 which is cyclized to 1-(4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl)-5-methyl-3-aryl-1,3,5-triazinane-2-thiones (3a-h) and 3- (4-(1H-imidazo[4,5-b]pyridine-2-yl)phenyl)-5-aryl-1,3,5-oxadiazinane-4-thiones (4a-h). All the compounds are analysed by 1H NMR and Mass spectra.


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