A convenient method was established for the preparation of 2-(2-hydroxyaryl)quinazolin-4(3H)-one derivatives via reaction of oaminobenzamide and substituted salicylaldehyde using [Hmim]HSO4 (10 mol %) as a catalyst. All prepared derivatives were tested for inhibition of cancer cell. The primary assays reveals that some of the prepared derivatives present considerably good inhibition activities against human breast cancer cell (MCF7) compared with the control (Adriamysin) which might be extended as lead scaffold for potential anticancer agents.
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