Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


A highly regioselective synthesis of spiro [oxindole-chromanone]pyrrolidines and pyrrolizines through 1,3-dipolarcycloaddition protocol

Author(s): Scholastica Mary Vithiya. B., Shanmugapriya. A. and Augustine Arul Prasad. T.

Intermolecular 1,3-dipolar-cycloaddition reaction of azomethine ylides, generated through decarboxylation route, with (E)-3-arylidene-4- chromanones as dipolarophiles has been investigated. A new class of functionalized spirooxindoles with pyrrolidine and pyrrolizines framework has been synthesized with high regioselectivity. The structures were established by spectroscopic techniques as well as single crystal X-ray analysis.