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A highly regioselective synthesis of spiro [oxindole-chromanone]pyrrolidines and pyrrolizines through 1,3-dipolarcycloaddition protocol | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

A highly regioselective synthesis of spiro [oxindole-chromanone]pyrrolidines and pyrrolizines through 1,3-dipolarcycloaddition protocol

Author(s): Scholastica Mary Vithiya. B., Shanmugapriya. A. and Augustine Arul Prasad. T.

Intermolecular 1,3-dipolar-cycloaddition reaction of azomethine ylides, generated through decarboxylation route, with (E)-3-arylidene-4- chromanones as dipolarophiles has been investigated. A new class of functionalized spirooxindoles with pyrrolidine and pyrrolizines framework has been synthesized with high regioselectivity. The structures were established by spectroscopic techniques as well as single crystal X-ray analysis.


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