Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


A Neolignan from Cycas sancti-lasallei

Author(s): Consolacion Y. Ragasa, Vincent Antonio S. Ng, Esperanza Maribel G. Agoo, Chien-Chang Shen

Chemical investigation of the dichloromethane extract of the leaflets of Cycas sancti-lasallei, a plant endemic to the Philippines, led to the isolation of a neolignan, 2-[2-hydroxy-5-(3-hydroxypropyl)-3-methoxyphenyl]-1-(4-hydroxy- 3-methoxyphenyl)propane-1,3-diol (1), phytyl fatty acid ester (2), lutein (3), chlorophyll a (4), and a mixture of stigmasterol (5a) and β-sitosterol (5b). The structure of 1 was elucidated by extensive 1D and 2D NMR spectroscopy.