Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


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A new and alternate synthesis of Linezolid: An antibacterial agent

Author(s): K. Chandra Babu, R. Buchi Reddy, L. Gangaiah, G. Madhusudhan and K. Mukkanti

A New and alternate syntheses of Linezolid, an antibacterial agent are reported from by employing two different approaches and finalized the meritorious one. The key step in both the approaches involves N-alkylation of 3-fluoro-4-morpholinobenzenamine 3 with respective compounds by changing the leaving functionalities on other end and followed by functional group transformations yielded an antibacterial agent Linezolid. Among the both, later is more efficient one with respect to improved overall yield, easy process and less number of steps.


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