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A new family of 1,2,5-thiadiazolidine 1,1-dioxides: Synthesis, structure and antibacterial activity | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

A new family of 1,2,5-thiadiazolidine 1,1-dioxides: Synthesis, structure and antibacterial activity

Author(s): Amira A, K’tir H, Becheker I.2,Ouarna S., Inguimbert N., Berredjem H., Berredjem M., Aouf N-E.

A convenient synthesis of novel N-N’-substituted 1,2,5-thiadiazolidine 1,1-dioxides starting from amino acids is reported in five step (reduction, carbamoylation-sulfamoylation, intermolecular cyclization via the Mitsunobu reaction and acylation). The newly synthesized compounds were characterized by IR, NMR and mass spectral analysis. Some of the newly synthesized compounds (4c and 4d) were examined for their antibacterial activity against several strains of Gram-positive and Gram-negative bacteria.


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