Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

A new process for the synthesis of enantiomerically pure R-(+)-Npropargyl-1-aminoindan mesylate(Rasagiline mesylate)

Author(s): K. Tatendra Reddy, K. Suneel Kumar, G. Omprakash, P. K. Dubey,

A new processdeveloped for the synthesis of enantiomerically pure R-(+)-N-propargyl-1- aminoindan mesylate(Rasagiline mesylate) by using K2HPO4/Triethylbenzylammonium chloride (TEBAC) as a reagent. This approach controls the formation of other isomerS-(-)-N-propargyl- 1-aminoindane. This new process may be useful for the preparation of enantiomerically pure Rasagiline mesylatein commercial scale with good yields.


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