Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.
Abstract
A new route for the synthesis of (R)- & (S)- 2-((2-oxooxazolidin-5- yl)methyl)isoindoline-1,3-dione: A key chiral building block
Author(s): G. Ravi Babu, P. Venkateshwarlu, S. Yellamanda Rao, G. Madhusudhan and K. MukkantiA new and efficient route for the synthesis of (R)- & (S)-2-((2-oxooxazolidin-5-yl)methyl) isoindoline-1,3-dione is described. The enantiopurity of the synthesized two stereoisomers of 2- ((2-oxooxazolidin-5-yl)methyl)isoindoline-1,3-dione, is established using chiral high performance liquid chromatography (HPLC) i.e. enantiomeric excess (ee) of R & S isomers are 99.5% and 99.6% respectively. This route also involves the synthesis of a key chiral constituent, (R)- & (S)5-(chloromethyl) oxazolidin-2-one.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 25868
Der Pharma Chemica received 25868 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
DOWNLOADS
