A new and efficient route for the synthesis of (R)- & (S)-2-((2-oxooxazolidin-5-yl)methyl) isoindoline-1,3-dione is described. The enantiopurity of the synthesized two stereoisomers of 2- ((2-oxooxazolidin-5-yl)methyl)isoindoline-1,3-dione, is established using chiral high performance liquid chromatography (HPLC) i.e. enantiomeric excess (ee) of R & S isomers are 99.5% and 99.6% respectively. This route also involves the synthesis of a key chiral constituent, (R)- & (S)5-(chloromethyl) oxazolidin-2-one.
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