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A note on the inhibition of steroid 11├?┬▓-hydroxylase, aldosterone synthase and aromatase by a series of coumarin derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

A note on the inhibition of steroid 11├?┬▓-hydroxylase, aldosterone synthase and aromatase by a series of coumarin derivatives

Author(s): Juan S. G├â┬â├ć┬ĺ├â┬é├é┬│mez-Jeria, Gaston A. Kpotin

The relationships between the inhibition of steroid 11β-hydroxylase, aldosterone synthase and aromatase enzymes and the electronic structure of a group of coumarin derivatives was analyzed. We obtained statistically significant results for the inhibition of the three enzymes. Some specific molecule-enzyme interactions are suggested. The corresponding pharmacophores were built. Finally, some suggestions that could improve the inhibitory capacity are proposed.


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