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A novel and efficient green methodology for the synthesis of meso-substituted dipyrromethanes | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

A novel and efficient green methodology for the synthesis of meso-substituted dipyrromethanes

Author(s): Amit Kumar Rawat and SMS Chauhan*

Meso-substituted dipyrromethanes were synthesized in excellent yields by the one-pot condensation of aldehyde/ketone and pyrrole in the presence of catalytic amount of the inexpensive, readily available and non-toxic inorganic acid in aqueous media at room temperature. In this reaction the products were obtained in short reaction time and easy operation under mild conditions without using any strong acid and minimize the organic solvents. Dipyrromethanes were filtered in high purity without use of flash chromatography.


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