Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

A novel method for estimation of Raloxifene Hydrochloride in bulk and pharmaceutical preparations by Visible Spectrophotometry

Author(s): B Kalyanaramu, K Raghubabu, Y Vamsi Kumar and V Jagannadharao

A simple and sensitive visible spectrophotometric method is described for the determination of raloxifene hydrochloride in bulk and pharmaceutical preparations based on the formation of dark green colored molecular complex with sodium nitroprusside in presence of hydroxyl amine under alkaline conditions and exhibiting λ max at 720 nm. The Regression analysis of Beer’s Law plot showed good correlation in a general concentration range of 8-24μg/ml with correlation coefficient (r= 0.999). The proposed method is validated with respect to accuracy, precision, linearity and limit of detection. The suggested procedure is successfully applied to the determination of the drug in pharmaceutical preparation, with high percentage of recovery, good accuracy and precision. The results of analysis have been validated statistically by repeatability and recovery studies. The results are found satisfactory and reproducible. The method is applied successfully for the estimation raloxifene in tablet form without the interference of excipients.


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