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A rapid and efficient route to synthesis of 2-amino-4H-pyran-3-carbonitrile derivatives in the presence of L-proline and their antimicrobial activity | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

A rapid and efficient route to synthesis of 2-amino-4H-pyran-3-carbonitrile derivatives in the presence of L-proline and their antimicrobial activity

Author(s): Anil Kumar Verma, Abha Bishnoi, Shaheen Fatma, Amrita Srivastava and Vineeta Singh

An efficient and mild method for the synthesis of 2-amino-4H-pyran-3-carbonitriles via coupling reaction of malononitrile and α,α’Bis(benzylidine) cyclohexanones in the presence of L-proline as a catalyst and acetonitrile as a solvent has been described. This method is a good option to obtain the title compounds in quantitative yields in shorter reaction times and in a simple way. The synthesized compounds were bio-evaluated for their possible antimicrobial activity against a panel of gram-positive and gram-negative bacterial strains and fungal strains by the known methods.


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