GET THE APP

A Rapid and Efficient Synthesis of 2,2',2''-(nitrilotris(ethane-2,1-diyl))tris(benzo [d][1,2]selenazol-3(2H)-one) and its Antioxidant Activity | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

A Rapid and Efficient Synthesis of 2,2',2''-(nitrilotris(ethane-2,1-diyl))tris(benzo [d][1,2]selenazol-3(2H)-one) and its Antioxidant Activity

Author(s): Devappa S. Lamani* and Mamata Singh

In the present communication an efficient method for the preparation of stable 2,2',2''-(nitrilotris(ethane-2,1-diyl)) tris(benzo[d][1,2]selenazol-3(2H)-one) has been developed. The reported compound benzoselenazol was achieved when 2, 2’-Selenobenzoyl chloride were treated with N,N-bis(2-aminoethyl)ethane-1,2-diamine over 1h. The reported structure was systematically characterized by 1H, 13C, 77Se NMR and mass spectroscopic techniques. In addition to synthesis and characterization the glutathione peroxidase (GPx) mimetic activity of newly synthesized compound were investigated. It is observed that the reported compound shows significant antioxidant activity in contrast with reference standard ebselen.


Full-Text PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry