A Review on Synthetic Methods for Preparation of Praziquantel | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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A Review on Synthetic Methods for Preparation of Praziquantel

Author(s): Pranaya P Dhawle, Anita S Goswami Giri

Praziquantel is synthesized pyrazineisoquinoline derivative having wide anthelmintic activity, and commonly used for treating all kinds of schistosomiasis. Synthesis of praziquantel generally involved diversified steps like Imino-Diels alder reaction, condensation, Ugi reaction, Nacylation, substitution, cyclisation and acylation followed by crystallization. It demonstrated high efficacy, low toxicity, short course treatment easy to use and affordability. Hence, present review is discussed landmarks of praziquantel with its process of preparation and application.

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