Plantago major Lbelongs to the plant family of plantain family Plantaginaceae, The plant is native to most of Europe and northern and central Asia, but has widely naturalized elsewhere in the world. The aim of this study was to overview pharmacological properties of Plantago .This review article was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases .The initial search strategy identified about 102 references. In this study,44studies was accepted for further screening and met all our inclusion criteria [in English, full text, therapeutic effects of Plantago major L and dated mainly from the year 1992 to 2016.The search terms were “Plantago major L”, “therapeutic properties”, “pharmacological effects”. It is commonly used for itsChemotherapeutic effect, Antioxidant effect ,Antitumoral effect ,Biological effect ,Antiviral and Immunoenhancing effect ,Mechanical effect Antimicrobial effect, Hematopoietic effect, Anti-cancer effect, Antioxidant effect, wound healing, Neutrophil Respiratory Burst. Although the results from this review are quite promising for the use of Plantago major Las a multi-purpose medicinal agent, several limitations currently exist in the current literature. While Plantago major Lhas been used successfully in Ayurvedic medicine for centuries, more clinical trials should be conducted to support its therapeutic use. It is also important to recognize that Plantago may be effective not only in isolation, but may actually have a potentiating effect when given in combination with other herbs or drugs.