The most well-known reasons for peptic ulcer sickness are Helicobacter pylori disease and utilization of Non-steroidal anti-inflammatory drugs. Urea breath tests and stool antigen tests are generally precise for recognizing Helicobacter pylori disease and can be utilized to affirm fix; serologic tests are a helpful however less exact other option and can't be utilized to affirm fix. Constant utilization of NSAIDs in patients with Helicobacter pylori contamination expands the danger of peptic ulcer malady. Suggested treatments for forestalling peptic ulcer sickness in these patients incorporate proton pump inhibitors and misoprostol. Medication conveyance frameworks that unequivocally control the discharge rates or target medications to a particular site enormously affect the medicinal services framework particularly peptic ulcer the management. Circadian rhythm can be characterized as endogenous sub-atomic time-keeping frameworks that are associated with activating day by day vacillations in different physiological and biochemical procedures. This article expects to give a reasonable review of the most recent advances in the pathogenesis of peptic ulcers, advancement of chronotherapy in treating peptic ulcer, impact of herbal therapies in treatment of peptic ulcer complications related with analgesics and anti-inflammatory drugs and the neglected needs as far as our insight and the management of this inexorably testing condition.