The CO2, air, oxygen and special gases effluence and contamination in compressed gas cylinders during storage and transportation resulting into localised pitting corrosion of the storage and conveying metal is a major challenge in oil and gas sector. In an attempt to address this, the inhibition influence of Ketoconazole (KCZ) drug performance on the electrochemical corrosion behaviour of type AA-6063 aluminium alloy in 1 M H2SO4 solutions was studied through weight loss method and potentiodynamic polarization test. The effect of inhibitor concentration was considered from 0.1-1.0% g/v. The results obtained showed that the drug compound performed effectively in acid solutions with average ketoconazole drug inhibition efficiency above 50% in H2SO4 acid from weight loss and potentiodynamic polarization test respectively. Furthermore from corrosion propagation it was revealed that the adsorption of ketoconazole drug onto the AA-6063 aluminium was through chemisorption and mixed type system whereby the redox activity initiating corrosion and the electrolytic transport of corrosion propagation were concurrently intimidated by the absorbed molecules and interferences of the species atoms. The structural properties examined by high resolution scanning electron microscope equipped with energy dispersive spectrometer [SEM/EDX] indicate a passive and less deterioration of AA-6063 aluminium alloy. The adsorption characteristics of the compound were determined to obey the Langmuir and Frumkin isotherm model.