Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Al(DS)3 Catalyzed, One-pot Synthesis and Antibacterial Studies of tetra substituted 1,4-Dihydropyridines in Aqueous Media

Author(s): Harvinder Singh Sohal , Manvinder Kaur, Anu Radha Thakur and Priyanka Parmar

Multi component, one pot synthesis of tetra substituted 1,4-dihydropyridine derivatives from the condensation of barbituric acid, methyl acetoacetate, aromatic aldehyde and ammonium acetate has been demonstrated using an highly efficient catalyst Aluminium tris(dodecyl sulphate) (Al(DS)3) in aqueous medium. The synthesized molecules were obtained in excellent yield and high purity without use of any additional methodology. Further, the synthesized compounds were found to exhibit potent antibacterial activity against various gram positive and gram negative bacterial strains as compared with the standard antibiotic drug (Amoxicillin).


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