Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Aluminum Acetylacetonate as a Recyclable Organometallic Catalyst for One- Pot Four-Component Synthesis of Pyranopyrazoles

Author(s): Adil Ziadi Chibane, Boudjemaa Boumoud, Taoues Boumoud and Abdelmadjid Debache

Multicomponent reactions exhibit higher atom economy and selectivity and generally produce fewer by-products compared to classical multistep syntheses, thus multicomponent reactions play an important role in modern organic chemistry. In this context, we report herein, an environmentally benign four-component reaction in aqueous medium at reflux temperature for the synthesis of 6-amino-5-cyano-3-methyl-4-aryl/heteroaryl-2H,4H-dihydropyrano[2,3- c]pyrazoles in the presence of aluminum acetylacetonate as a recycled organometallic catalyst.


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