Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Amination of Chitosan and Its Application in Wastewater Treatment in Kitchener Drain in Egypt

Author(s): El-Refaie Kenawy, H Mansour, Samia El-Sigeny, Hazem Fathy

Chitosan (CS) is a non-toxic polyamino saccharide available in a variety of useful forms. The current work, the graft copolymerization of Acrylonitrile (AN) onto CS was carried out using Ceric Ammonium Nitrate (CAN) as an initiator. CS derivatives were prepared by treatment with Polyethylene Imine (PEI) and 1,3-Diamino Propane (DAP) to produce copolymers [(CS-g-(PAN)/PEI)] and [(CS-g-(PAN)/DAP)] respectively. Thermo-gravimetric (TGA) and Fourier Transform Infrared (FT-IR) spectroscopic analyses as well as Electron Scanning Microscopy (SEM) and Transmission Electron Microscopy (TEM) were used to characterize the obtained products. The products were tested toward their ability to uptake transition metal ions as Pb(II) and Cu(II) from their aqueous solutions. The uptake was determined by atomic adsorption. The modified CS copolymers showed higher capacity of adsorption than pure CS. [CS-g-(PAN)/PEI] showed lower capacity of adsorption compared to [CS-g-(PAN)/DAP]. The antimicrobial activity of the modified copolymers was tested against various microorganisms (Staphylococcus aureus, Escherichia coli and Salmonella). [CS-g-(PAN)/PEI] showed reasonable antibacterial activity against three bacterial strains.