Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

ß-Amyrin acetate of ethyl acetate extract of the bark plant artocarpus camansi and its antidiabetic activity

Author(s): Rosnani Nasution, Marianne and Hijjatin Nur

Isolation of chemical compounds from ethyl acetate extract of the stem bark of Artocarpus camansi (kulu) and antidiabetic activity test against male Swiss Webster mice using glucose tolerance has been done. Maceration with ethyl acetate of the bark A. camansi to yield concentrated ethyl acetate extract. Ethyl acetate extracts was obtained then separated by column chromatography to give fractions group A and fractions group B, the ethyl acetate extract also were characterized by GC-MS. The fraction group A then separated by column chromatography to give A isolate, the isolate was characterized by 1H-NMR, also was measured its activity to antidiabetic, while fractions group B was measured only its activity to antidiabetic. Based on analyses spectra MS and 1H-NMR suggested that the A isolate was ß-amyrin acetate. Test results antidiabetic ethyl acetate extract, fractions group A (contain A isolate) and fractions of group B at a dose of 50 mg fraction/kg bw respectively showed a decrease in blood glucose levels in the mice at 60th minutes to as much as 47 mg / dL; 59 mg / dL; 59.67 mg / dL and in the 90th minute was able to lower blood glucose levels of mice were 37.33 mg / dL, 43.33 mg / dL, 71.33 mg / dL


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