Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


An eco-friendly solvent free one pot multi-component synthesis of Coumarin thiazolidinone derivatives

Author(s): Santosh A. Jadhav, Mahesh G. Shioorkar, Omprakash S. Chavan, Rahul V. Chavan, D. B. Shinde and R. K. Pardeshi

8-ethoxy-3-acetyl coumarin 1, thiosemicarbazide 2 was condensed under microwave irradition gives 2-(1-(8-ethoxy- 2-oxo-2H-chromen-3-yl) ethylidene) hydrazinecarbothioamide 3 then 3, chloroacetyl chloride 4, substituted aryl aldehydes 5, were condensed in presence of alum catalyst to formed 5-benzylidene-2-((E)-(1-(8-ethoxy-2-oxo-2Hchromen- 3yl)ethylidene)hydrazono) thiazolidin-4-one 6, by simple grinding technique at room temperature under solvent free condition. Synthesized compounds were confirmed by IR, NMR, Mass and CHN analysis.