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An Efficient and Alternative Large Scale Synthesis of Nardril (Phenelzine Sulfate) | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

An Efficient and Alternative Large Scale Synthesis of Nardril (Phenelzine Sulfate)

Author(s): Rajesh Kumar R, Prasada Raju VVNKV, Murthy C

Facile and efficient,large scale synthesis of Nardril (Phenelzine sulfate) (5) can be prepared by alternative method from Phenethylamine (1) and 3, 3-pentamethylene oxaziridine (2) in the presence of acid catalyst. The main advantage of this method is low cost, easy work up and gave high yield of product. This method is very favorable for large scale synthesis of nardril in pharmaceutical industries.


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