An Efficient and Practical Synthesis of Dimethyl 2-chloromalonate | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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An Efficient and Practical Synthesis of Dimethyl 2-chloromalonate

Author(s): G. Ravi Babu, T. Rajesh, R. Nagarjuna, A. V. Gopi Krishna & G. Madhusudhan

Dimethyl 2-chloromalonate, an important reagent unavailable commercially in high chemical purity, has now been successfully produced on pilot plant scale by chlorination of readily available dimethyl malonate with sulfuryl chloride.


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