Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


An Efficient One-pot Synthesis of some New Pyrazolyl Appended 1,3,4-Oxadiazole Derivatives as Antibacterial and Antioxidant agents

Author(s): Ajay N Ambhore, Rahul D Kamble, Pratima P Mogle, Shrikant V Hese, Shuddhodan N Kadam, Madhav J Hebade, Sonali S Kamble, Rajesh N Gacche, Bhaskar S Dawane

Synthesis of 2(3,5-disubstituted)-1H-pyrazol-4-yl-thio-5-(pyridin-4-yl)1,3,4-oxadiazoles was achieved via one pot multi-component reaction of 1-(4-substitutedphenyl)-2-((5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)thio)ethanone, substituted benzaldehydes and hydrazine hydrate by using Bleaching earth clay (pH 12.5, 10 wt%) and Polyethyleneglycol (PEG-400) as a green reaction media. The method is found an efficient, eco-friendly and catalyst recycled for five times with no significant loss in the yield of product. All the synthesized compounds were characterized by spectral data and screened in vitro for their antibacterial and antioxidant activities. The compounds 5s and 5l have shown considerable antioxidant and antimicrobial activity, however all other synthesized compounds demonstrated moderate activities