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An efficient route to synthesis of pyrazoline carboxamides bearing thiophene moiety as antimicrobial agents
Author(s): S. P. Vijaychand, G. Pavithra, K. R. Raghavendra and K. Ajay Kumar
A series of new pyrazoline carbothioamides bearing thiophene moiety were synthesized by simple one pot procedure. The cyclocondensation reaction of chalcones 1a-g and semicarbazine 2 in the presence potassium hydroxide in ethanol yielded 5-(4-aryl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboxamides 3a-g in excellent yield. The synthesized new products were characterized by 1H NMR, 13C NMR, Mass spectral studies and elemental analysis. The compounds were tested for their antimicrobial susceptibility against different bacterium and fungi species.