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An Efficient Synthesis And Antibacterial Activity Of Some Novel Isoxazoles, Pyrimidinthiones And Pyrimidinones | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

An Efficient Synthesis And Antibacterial Activity Of Some Novel Isoxazoles, Pyrimidinthiones And Pyrimidinones

Author(s): A. N. Solankee, G. A. Patel, R. B. Patel, B. K. P. Patel

The title compounds (7a-e), (8a-e) and (9a-e) have been prepared from chalcones (6a-e) having s-triazine nucleus. These chalcones on cyclisation with hydroxyl amine hydrochloride in the presence of alkali give isoxazoles (7a-e). Chalcones (6a-e) on condensation with thiourea and urea in the presence of alkali give pyrimidinthiones (8a-e) and pyrimidin-2-ones (9a-e) respectively. Structures of newly synthesised compounds were established on the basis of their elemental analysis, IR and 1H NMR spectral data. All the synthesised compounds have been screened for their antibacterial activity.


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