Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


An efficient synthesis with antimicrobial screenin g of N-methyl derivative of 4-(2-bromonaphthalen-6-yl)-6-aryl-6H-1,3-thiazin-2- amines

Author(s): N. Prakash and N. Ingarsal*

Biologically active N-Methyl derivative of 4-(2-bro monaphthalen-6-yl)-6-aryl-6H-1,3-thiazin-2-amines h ave been synthesized by the reaction of N-Methylthiourea wit h 1-(2-bromonaphthalen-6-yl)-3-arylprop-2-en-1-ones which were obtained from the Claisen-Shimidt reaction of 1-(2-bromonaphthalen-6-yl)ethanone in the presenc e of base. The structure of the synthesized N-Methyl-1,3-thiaz ines were determined by using IR and NMR spectral measurements. The antimicrobial activities of the s ynthesized compounds showed very potent activity ag ainst the fungi, Aspergillus nigar and the bacteria, Escherch ia coli.