Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

An elegant method for the preparation of 3-cyanomethyl derivatives of imidazo[1,2-a]pyridines

Author(s): Rajendiran Chinnapillai, Ravikumar Reddy Nallamaddi, Eswaraprasad Rao Daliparthi and Eswaraiah Poguri

A series of 3-cyanomethylimidazo[1,2-a]pyridine derivatives ( 4 ) have been synthesized by using a novel method of utilizing ethylchloroformate as alkylating agent for making quaternary ammonium salts (7) from 3- (dimethylamino)methyl imidazo[1,2-a]pyridines (6) followed by cyanation. This method is hitherto unknown in the literature and the process is elegant and simple with excellent yields.


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