Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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An Expedient Synthesis of Ethyl 5-Acetyl-1,2,4,4a,5,6-Hexahydro Benzo-[G][1,4]Oxazino[4,3-A][1,8]Naphthyridine-5-Carboxylate from 2-Cholro-3-Formyl Quinoline

Author(s): Sathiyamoorthy S, Jemima D, Pitchai P, Makhanya TR, Gengan RM

The multi-component reactions of organic molecules are an important strategy for the synthesis of biologically active fused quinoline derivatives. This can be classified as a green strategy which organic chemists are reporting on a regular basis. The current study describes a strategy to synthesize ethyl 5-acetyl-1,2,4,4a,5,6-hexahydrobenzo[g][1,4]oxazino[4,3-a][1,8]naphthyridine-5-carboxylate from 2-chloro-3-formyl quinoline, a readily available and cost effective substrate.

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