Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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An Improved Synthesis, Characterization and Bioevalution of Schiff Base Containing Benzimidazole Moiety Catalyzed by Methane Sulfonic Acid

Author(s): Krishna Rao N, Surendra Babu MS, Ramana N, Tentu Nageswara Rao, Basaveswara Rao MV, Karri Apparao

In present report an improved process for the synthesis for some novel Schiff bases from 2-amino benzimidazole with 5-substituted indole-3-carbaldehyde using methane sulfonic acid in free solvent at room temperature. The intermediate moiety (2-aminobenzimidazol) can be synthesized from o-phenyl diamine with cyanobromide in the presence of acid medium. All the newly synthesized compounds were confirmed by the advanced spectroscopic data (1H-NMR, 13C-NMR and LC-MS) and also structural determination were calculated by elemental analysis. In addition to all compounds were screened by their biological activities.


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