In present report an improved process for the synthesis for some novel Schiff bases from 2-amino benzimidazole with 5-substituted indole-3-carbaldehyde using methane sulfonic acid in free solvent at room temperature. The intermediate moiety (2-aminobenzimidazol) can be synthesized from o-phenyl diamine with cyanobromide in the presence of acid medium. All the newly synthesized compounds were confirmed by the advanced spectroscopic data (1H-NMR, 13C-NMR and LC-MS) and also structural determination were calculated by elemental analysis. In addition to all compounds were screened by their biological activities.
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