GET THE APP

Analgesic triterpenes from Ardisia cf. Elliptica (Subgenus: Tinus) (Myrsinaceae) | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Analgesic triterpenes from Ardisia cf. Elliptica (Subgenus: Tinus) (Myrsinaceae)

Author(s): Dennis D. Raga, Marie Luciene S. Diezmos, Abigail Cheska C. Orantia, Marvin James A. Lo,Juan Carlo P. Evangelista, Sang Hyeon Kim, Chien-Chang Shen, Consolacion Y. Ragasa

The dichloromethane extract of the air-dried leaves of Ardisia cf. elliptica (subgenus Tinus) afforded a mixture of bauerenol (1a), α-amyrin (1b) and β-amyrin (1c). Their structures were identified by NMR spectroscopy. The mixtures of triterpenes (1a-1c) at ratios of 2:2:1 and 1:1:1 were tested for their analgesic property using the hot plate, tail flick and acetic acid-induced writhing assays. Results from the hot plate assay indicate that 5, 10, and 50 mg kg-1 body weight (BW) of 1a-1c (2:2:1) had analgesic activity comparable to the positive drug control (Diclofenac) at 75 min. Both ratios of 1a-1c were found not effective in the tail flick assay. The mixture (2:2:1) was found most effective in the acetic acid writhing assay. Reduced analgesic activity however was observed in the other mixture (1:1:1).


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 15261

Der Pharma Chemica received 15261 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry