Analgesic triterpenes from Ardisia cf. Elliptica (Subgenus: Tinus) (Myrsinaceae) | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Analgesic triterpenes from Ardisia cf. Elliptica (Subgenus: Tinus) (Myrsinaceae)

Author(s): Dennis D. Raga, Marie Luciene S. Diezmos, Abigail Cheska C. Orantia, Marvin James A. Lo,Juan Carlo P. Evangelista, Sang Hyeon Kim, Chien-Chang Shen, Consolacion Y. Ragasa

The dichloromethane extract of the air-dried leaves of Ardisia cf. elliptica (subgenus Tinus) afforded a mixture of bauerenol (1a), α-amyrin (1b) and β-amyrin (1c). Their structures were identified by NMR spectroscopy. The mixtures of triterpenes (1a-1c) at ratios of 2:2:1 and 1:1:1 were tested for their analgesic property using the hot plate, tail flick and acetic acid-induced writhing assays. Results from the hot plate assay indicate that 5, 10, and 50 mg kg-1 body weight (BW) of 1a-1c (2:2:1) had analgesic activity comparable to the positive drug control (Diclofenac) at 75 min. Both ratios of 1a-1c were found not effective in the tail flick assay. The mixture (2:2:1) was found most effective in the acetic acid writhing assay. Reduced analgesic activity however was observed in the other mixture (1:1:1).


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