Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Analytical methodologies for determination of amitriptyline and its metabolite nortriptyline: A review

Author(s): Asma Khatoon, Siti Hamidah Mohd. Setapar, Akil Ahmad and Lee Nian-Yian

Amitrityline and its metabolite nortriptiline are tricyclic antidepressant drugs widely used for the treatment of several psychiatric disorders. Several methods have been published for the determination of these two antidepressant drugs in pharmaceuticals, biological materials and environmental samples. In this review some of analytical techniques such as ultraviolet/visible spectrophotometry, fluorimetry, capillary electrophoresis, and chromatographic methods (gaschromatography and high-performance liquid chromatography) were discussed. Although HPLC and capillary electrophoresis methods are extensively employed in spite of that UV/VIS spectrophotometry are still popular because of the inherent simplicity, low cost, and reliability for determination of drugs in pharmaceutical preparations.