A new series of novel thiosemicarbazides derivatives were synthesised and evaluated for antibacterial activity against Gram positive and negative bacterias. In the present study, synthesis of hydrazine-carbothioate and hydrazine-carbothioamide representing thiosemicarbazide class of compounds, was accomplished. All the newly synthesized compounds were characterized by their spectral data and further used to estimate their ability towards antibacterial activity. Antibacterial activity was carried out by serial dilution method using Streptomycin as standard drug. Compound N, N-bis (4-chlorophenyl) hydrazine-1, 2-dicarbothioamide (3g) has activity compared to that of the standard used.
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