Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


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Antibacterial Properties of Mn (II), Co (II), Ni (II) and Zn (II) Complex of derived from Schiff base Trimethoprim

Author(s): Sunil Joshi, Vatsala Pawar and V.Uma

In the present study, Schiff bases have been synthesized by the condensation of Trimethoprim with p-Chlorobenzaldehyde and Vanillin respectively in methanol. Further their metal complexes have been synthesized by metal salts of Mn (II), Co (II), Ni (II) and Zn (II). Structural assignment of these compounds has been made on the basis of molecular weight, molar conductivities, elemental analysis, UV, IR and 1HNMR spectral data. Synthesized compounds were screened for their in vitro growth inhibiting activity against different strains of bacteria viz., gram positive Staphylococcus aureus, Bacillus licheniformis, Micrococcus luteus and gram negetive Escherichia coli and were compared with the standard antibiotic oflaxocin


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