Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Antibacterial, whitening, and anti-wrinkling effects of essential oil from Curcuma aromatica leaves

Author(s): Jong-Seok Kang, Min-Jin Kim, Ju Mi Hyun, Juyeong Lee, Minkyung Cho, Yooan Kang, Duk Soo Kim, Nam Ho Lee and Chang-Gu Hyun

In this study, the chemical compositions of steam-distilled essential oil from the leaves of Curcuma aromatica, as well as its antibacterial, anti-elastase, and anti-melanogenic activities, were investigated for the first time. The chemical constituents of the essential oil were further analyzed by GC–MS and were found to be α-terpinolene (44.81%), 1,8-cineole (13.88%), and bicyclo[3.1.1]heptane, 6,6-dimethyl-2-methylene- (11.76%). The antibacterial activities of C. aromatica oil (CAO) against drug-susceptible and drug-resistant skin pathogens were also examined. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) values indicated that CAO has excellent antibacterial activities. The MIC of CAO against drug-susceptible and drug-resistant skin pathogens ranged from 70 to 400 μg/mL. In addition, the capacity of the CAO to inhibit elastase, a key enzyme known to be involved in skin wrinkle formation, was investigated. CAO contained moderate anti-elastase activity (IC50: 667.88 μg/mL). Furthermore, CAO reduced α-melanocyte stimulating hormone (α-MSH)-induced melanin production in B16/F10 murine melanoma cells, indicating that it has anti-melanogenic effects. These findings demonstrate that CAO has great potential for use in promoting human skin health.


PDF

FIND ARTICLES
SCImago Journal & Country Rank
 
Erkek öyle sert ve acımaz sikiyor ki bayan çaresiz bir şekilde tırtıl misali sikiş yataktan aşağı doğru kayıyor fakat hem adam hemde kadın aşırı mobil porno derecede zevk alıyorlar Uzun zamandır karısı ile ilgili planları olan türk porno adam onu başkaları sikerken hayal ediyor bu durumu karısından sikiş izle gizliyordu fakat bir gün adamın moralinin bozuk olduğunu anlayan karısı sikiş ona ne olduğunu sordu ve adamda ona her şeyi anlatmıştı karısı bu porno resim durumdan Büyük zenci yarağı sevenler için özel olarak eklenmiş videomuz türk porno kalın ve damarlı zenci siki arayıp bulamayanlar için özel olarak sikiş izle yayınlanmıştır filmde ise sarışın zengin sürtük büyük mobil sikiş kalın damarlı alet sevdiğini bir çok kez dile getirmiş