5-[1-(Aryl)-5-phenyl-1H-pyrazol-3-yl]-4-phenyl-2,4-dihydro[1,2,4]triazole-3-thione derivatives 1a-c were reacted with chloropropanol, chloroacetone, chlorodiethyl ether and epichlorohydrine to afford the corresponding acyclonucleosides 2a-c-5a-c, respectively. Also, compound 1c was reacted with formaldehyde and 4-chloroaniline or piperidine to give the corresponding Mannish products 6 and 7, respectively. In addition, 1c was reacted with acrylonitrile or benzoyl chloride to give N-triazole derivatives 8 and 9, respectively. The structures of newly synthesized compounds were confirmed by IR, 1H NMR, MS spectral data and elemental analysis. All the compounds were screened for their antibacterial and antifungal activities and they showed high activity compared with Ciprofloxacin and Fusidic acid as positive controls. The compounds 2b, 3b, 5b, 6 and 7 were screened for their anticancer activities against breast carcinoma (MCF7) and cervix carcinoma (HELA) human cell lines compared with Doxorubicin positive control. The detailed synthesis, spectroscopic data, antimicrobial and anticancer activities of some synthesized compounds were reported.
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