Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Antidiabetic Activity of ARA (Ficus racemosa) from Aceh

Author(s): Rosnani Nasution, Mustanir, Marianne, Anas Kausar

Isolation of chemical compounds from hexane extract of the stem bark of Ficus racemosa, starting by maceration of 3 kg of bark F. racemosa, and obtained 68 g of extract concentrated, then separated by gravity column to obtained 4 groups of fraction (A, B, C and D). Separation of the group fraction A was obtained isolates A4, allegedly -amyrin dodecanoic, which is based on spectroscopy by, Fourier Transform Infrared Spectroscopy (FTIR), Proton Nuclear Magnetic Resonance (1H-NMR) and Carbon-13 Nuclear Magnetic Resonance (13C-NMR) and also, Mass Spectrometry (MS). Antidiabetic activity by glucose tolerance in mice. Activity lowers blood sugar in mice at 30th min, sorted greatest to the smallest is fraction group D (200.67 mg/dl), the crude extract (99.00 mg/dl), fraction group of B (77.67 mg/dl), fraction group C (71.33 mg/dl), fraction group A (28.67 mg/dl) and isolates A4 (4.67 mg/dl). Activity lowers blood sugar in mice at 60th min, sorted greatest to the smallest is fraction group D (136.33 mg/dl), the crude extract (51.33 mg/dl), fraction group of B (12.00 mg/dl), while isolates A4 to raise blood glucose levels of 8.67 mg/dl, as well as fraction group of B and group fraction C, to raise the blood glucose respectively 39.00 mg/dl and 17.67 mg/dl. Activity lowers blood sugar in mice at 90th min, sorted greatest to the smallest, is the fraction group of D (46.33 mg/dl), isolates A4 (43.00 mg/dl), the group of fraction A (19.67 mg/dl), the fraction C group (6.67 mg/dl) and crude extract (4.33 mg/dl). Group fraction B, at the 90th min, to raise the blood glucose levels of mice of 36.33 mg/dl. Activity lowers blood sugar in mice at 120th min, sorted greatest to the smallest, respectively from fraction group of the D (44.33 mg/dl), group C fraction (29.33 mg/dl), group A fraction (25.67 mg/dl), fraction group B (12.67 mg/dl) and crude extract (3.00 mg/dl). Group D bark fraction F. racemosa more active than others at 30 min of treatment, the level of 95%, (P<0.05).


PDF