Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Antidiabetic Activity of Murbei (Morus alba) from Aceh

Author(s): Rosnani Nasution, Bastian Arifin, Marianne, Dedek Inayati

Leaves of Morus alba as much as 3 kg was macerated, with n-hexane, and produce hexane extracts as much as 59.51 g (1.98%). The hexane extract as much as 35 g, separated by gravity column and obtained four groups of fractions, namely the fraction A, B, C and D. Group fraction A, that is quite clean re chromatographed to obtain compounds A1. The compound of A1, then characterized by Proton Nuclear Magnetic Resonance (1H-NMR), Carbon-13 Proton Nuclear Magnetic Resonance (13C-NMR), Fourier-Transform Infrared Spectroscopy (FTIR) and Mass spectrometry, and A1 isolates is believed to Ar-turmerone. Antidiabetic test performed by the method of glucose tolerance. n-hexane extract, fraction group A, fraction group B, fraction group C, fractions group D and compound A1, respectively showed a decrease in blood glucose levels in mice at min 30th in the amount of 155.67, 147.00, 140, 226.33, 196 and 200.67 mg/dl. At min 60th, the six of samples lowering blood glucose levels in mice as much as 167, 175.33, 161.67, 162.67, 166 and 180 mg/dl. In the 90th min, the 6 of samples capable of lowering blood glucose levels in mice by 68, 66.33, 45.67, 62, 65.33 and 56.33 mg/dl. At min 120th, the six of samples capable of lowering blood glucose levels in mice as much as 50.67, 65, 36.67, 43.33 57.33 and 67.33 mg/dl. Isolates A1 and group fraction D was the most active lowers blood glucose Swiss Webster of mice, as compared to blood glucose of negative control of mice. All samples are not significantly different from the positive control, glibenclamide, (P<0.05), which shows all the samples are relatively active as the lowering of blood sugar. Keywords: Morus