Antidiarrheal, Antispasmodic and Antioxidant Properties of Extracts of Conyza Canadensis | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Antidiarrheal, Antispasmodic and Antioxidant Properties of Extracts of Conyza Canadensis

Author(s): Jamila El-Akhal*, Mohamed El Kabbaoui, Boukir Abdelatif, Tazi Abdelali, Bencheikh Rachid

Introduction: Conyza Canadensis is a medicinal plant widely used in traditional medicine in Morocco for the treatment of several health challenges. The present study aimed to investigate antidiarrheal, antispasmodic and antioxidant properties of aqueous methanolic and hydromethanolic extracts of C. Canadensis, to provide data on their mechanisms of action on Wistar rats and to reveal the main functional groups using Fourier Transform Infra-Red Spectroscopy (FTIR).

Methods: Antidiarrheal activity of aqueous and methanol extracts of C. Canadensis was assessed on Wistar rats at the doses of 50, 100 and 200 mg/kg body weight using castor oil-induced diarrhea, castor oil-induced enter pooling and small intestinal transit models. The Hydromethanolic extract was studied in the isolated rat jejunum, for antispasmodic property, using KCl (100 mM) or acetylcholine (Ach 10 µM) and in the absence and the presence of L-NAME (100 µM). DPPH and FRAP were used to study the antioxidant activity of aqueous extract. The functional chemical groups were determined by FTIR.

Results: C. Canadensis extracts inhibited antidiarrheal activity. The hydromethanolic extract caused a marked concentration-dependent relaxation in rats jejunum pre-contracted by acetylcholine (10 µM) or KCl (100 mM). The NO pathway activation seems not to be involved in the spasmolytic effect C. Canadensis exhibited powerful antioxidant potentiality using DPPH and FRAP as compared with gallic acid and BHT. Ketone, phenol and ester were found to be the main functional groups in C. Canadensis.

Conclusions: Our results strongly suggest that C. Canadensis presents promising natural source for the treatment of gastrointestinal disorders.


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