Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Antihypercholesterol activity of ethanol extract of Bauhinia hullettii Prain and its secondary metabolites

Author(s): Lenny Anwar*, Jhon Azmi and Herdini

In vivoantihypercholesterol assay of ethanol extract of Bauhinia hullettii Prainshowed real impact in decreasingtotal cholesterol level and the LDL (low density lipid)in male Wistar strainrats (Rattus norvegicus)significantly. This research indicated250 mg/kgbb of ethanol extract is the most effective dose to decreasetotal cholesterol level and LDL. The separation of secondary metabolites in this plant yielded one phenolic compound, 3,4,5-trihydroxybenzoate acid (1) and two flavanones, 5,7,3’,5’-tetrahydroxyflavanone (2) and 5,7,4’- trihydroxy-6-methylflavanone (3). These three compounds were reported for the first time in this plant.


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