Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Anti-inflammatory activity study of the 3-amino-2-thioxo-2,3- dihydrothieno[2,3-d]pyrimidin-4(1H)-one-6-carboxylic acid derivatives and their fused heterocyclic systems

Author(s): Sergiy V. Vlasov, Ganna L. Lytvynenko, Larysa V. Iakovlieva, Valentin P. Chernykh

The study of anti-inflammatory and analgesic activity of some 3-amino-2-thioxo-2,3-dihydrothieno[2,3-d]pyrimidin- 4(1H)-one-6-carboxylic acid derivatives, and the fused heterocyclic systems obtained by their modification allowed to find the compounds with the pharmacological effects similar to the effects of the drug "Ortofen" (diclofenac sodium). The ulcerogenity indices for the compounds obtained were found to be less than the index of the referencedrug; the acute toxicity study showed that the tested compounds are practically non-toxic. The results of docking study disclosed that some of the tested compounds may bind the active site of COX-2.