Antileishmanial activity is associated with diverse heterocyclic nucleus such as piperazine, pyrimidine, quinoline, azoles (imidazole, 1, 2, 4 triazole, isoxazole, pyrazole, thiazole, thiadiazole), quinazoline, acridine and indole. This review article covers different heterocyclic nucleus with their antileishmanial activity on different species of Leishmania parasite. Considering the therapeutic potential of these nucleuses, new drugs can be synthesized as antileishmanial agent. These compounds act by efficacious mechanism of action and provide result for the future medicines.
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