Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Antimicrobial activity of newly synthesized imidazolones, their oxadiazolyl and acyclic C-nucleosides

Author(s): Adel A. H. Abdel-Rahman, Shafey G. Donia, Ashraf A. F. Wasfy, Aly A. ALY and Amaal Y. El-Gazzar

A number of substituted new 2-(N-phthalimidomethyl)-4-chlorobenzylidene-5-imidazole derivatives in addition to their sugar hydrazones were newly synthesized. The antimicrobial activity of the prepared compounds was evaluated against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Aspergillus niger and Candida albicans. The sugar hydrazones analogues were the highly active compounds.


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