Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Antimicrobial Activity of Newly Synthesized Thiadiazoles, 5-benzyl-2Htetrazole and Their Nucleosides

Author(s): Mamdouh A. Sofan, Samy B. Said, Said H. Kandeel

A number of new substituted tetrazole and their hydrazide derivatives as well as the corresponding sugar hydrazone derivatives were synthesized and tested for their antimicrobial activity against Bacillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gram-negative), and Streptomyces species (Actinomycetes) and antifungal activity against four fungal strains namely, Aspergillus flavus, Aspergillus fumigates, Penicillium marneffei and Trichophyton mentagrophytes. The synthesized compounds displayed different degrees of antimicrobial activity.


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